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KMID : 0191120130280081154
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Journal of Korean Medical Science
2013 Volume.28 No. 8 p.1154 ~ p.1160
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15-Hydroxyprostaglandin Dehydrogenase in Colorectal Mucosa as a Potential Biomarker for Predicting Colorectal Neoplasms
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Lee Hyo-Jeong
Yang Dong-Hoon
Ryu Yeon-Mi
Song Mi-Yeoun
Song Ho-June
Jung Kee-Wook
Kim Kyung-Jo
Ye Byong-Duk
Byeon Jeong-Sik
Yang Suk-Kyun
Choi Eun-Kyung
Kim Jin-Ho
Myung Seung-Jae
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Abstract
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15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is downregulated during the early stages of colorectal carcinogenesis. The aim of the present study was to investigate the potential role of 15-PGDH in normal-appearing colorectal mucosa as a biomarker for predicting colorectal neoplasms. We obtained paired tumor and normal tissues from the surgical specimens of 32 sporadic colorectal cancer patients. mRNA expression of 15-PGDH was measured using a quantitative real-time PCR assay. We evaluated the association between 15-PGDH mRNA expression in normal-appearing mucosa, the presence of synchronous adenoma, and the cumulative incidence of metachronous adenoma. The relative 15-PGDH expression of normal-appearing mucosa in patients with synchronous adenoma was significantly lower than in patients without synchronous adenoma (0.71 vs 1.00, P = 0.044). The patients in the lowest tertile of 15-PGDH expression in normal-appearing mucosa were most likely to have synchronous adenoma (OR: 10.5, P = 0.024). Patients with low 15-PGDH expression in normal-appearing mucosa also demonstrated more advanced stage colorectal cancer (P = 0.045). However, there was no significant difference in the cumulative incidence of metachronous adenoma according to 15-PGDH mRNA expression in normal-appearing mucosa (P = 0.333). Hence, 15-PGDH in normal-appearing colorectal mucosa can be a useful biomarker of field effect for the prediction of sporadic synchronous neoplasms.
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KEYWORD
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15-Hydroxyprostaglandin Dehydrogenase, Biological Markers, Colorectal Neoplasms
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